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Ref Type Journal Article
PMID (25076298)
Authors Dhingra S, Fiel MI
Title Update on the new classification of hepatic adenomas: clinical, molecular, and pathologic characteristics.
Journal Archives of pathology & laboratory medicine
Vol 138
Issue 8
Date 2014 Aug
URL
Abstract Text Hepatic adenoma is an uncommon, benign, hepatic neoplasm that typically occurs in women of child-bearing age, often with a history of long-term use of oral contraceptive drugs. This is usually detected as an incidental mass lesion in a noncirrhotic liver during imaging studies. Pathologic evaluation by needle core biopsy remains the gold standard for diagnosis. Molecular studies have revealed that hepatic adenomas involve unique molecular pathways that are distinct from hepatocellular carcinoma. Based on these studies, a French collaborative group has recently proposed a molecular-pathologic classification for hepatic adenomas. In addition, advances in molecular studies have led to reclassification of the "telangiectatic variant of focal nodular hyperplasia" as "hepatic adenoma, inflammatory subtype."To review the proposed, new classification of hepatic adenoma and the changes in diagnostic workup in light of the above-mentioned developments.Review of published literature and illustrations from clinical case material.Definitive diagnosis of liver mass lesion on needle core biopsies has a decisive role in clinical management. With the advent of the new classification of hepatic adenomas and its prognostic implications, it is vital for pathologists to be aware of the morphologic features seen in different subtypes and the available diagnostic tools, such as immunohistochemistry, to help identify the correct subtype.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
HNF1A NCBI HNF-1A|HNF1|HNF4A|IDDM20|LFB1|MODY3|TCF-1|TCF1 HNF1A, HNF1 homeobox A, is a transcription factor that demonstrates tumor suppressor activity and plays a role in hepatocyte differentiation and glucose transport (PMID: 25233928, PMID: 26855178, PMID: 25076298). HNF1A inactivating mutations are associated with hepatic adenomas (PMID: 25076298) and may be associated with pancreatic tumorigenesis (PMID: 32154941). Tumor suppressor
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HNF1A inact mut hepatocellular adenoma not applicable N/A Clinical Study Diagnostic Inactivating mutations in HNF1A (TCF1) are used in the diagnosis of the HCA-H subtype of hepatocellular adenoma (PMID: 25076298, PMID: 26961851, PMID: 25434466). 25076298 25434466 26961851