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Ref Type
PMID
Authors V.T. Phan, E. Verner, M. Gerritsen, J.M. Bradshaw, D.M. Goldstein, R.J. Hill, D. Karr, J. LaStant, P. Nunn, D. Tam, J. Shu, J.O. Funk, K. Brameld
Title Irreversible Covalent Pan-FGFR Inhibitors are Highly Efficacious Against FGFR-dependent Cancers
Journal European Journal of Cancer
Vol
Issue
Date
URL http://www.ejcancer.com/article/S0959-8049%2814%2970609-4/pdf
Abstract Text Eu J Cancer Nov 2014 Volume 50, Supplement 6, Page 157

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
PRN1109 PRN1109 2 0
PRN1371 PRN1371 26 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
PRN1109 PRN1109 is a pan-FGFR inhibitor that blocks FGF/FGFR signaling, leading to anti-tumor activities (Eu J Cancer 2014 Vol 50, Suppl 6:157).
PRN1371 FGFR Inhibitor (Pan) 18 PRN1371 is an irreversible inhibitor of FGFR1-4 that blocks FGFR signaling, leading to apoptosis and tumor regression in animal models (Eu J Cancer 2014 Vol 50, Suppl 6:157, PMID: 31167419).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 - TACC3 urinary bladder cancer sensitive PRN1109 Preclinical - Cell line xenograft Actionable In a preclinical study, PRN1109 treatment resulted in tumor regression in bladder cancer cell line xenograft models harboring FGFR3-TACC3 fusion (Eu J Cancer 2014 Vol 50, Suppl 6:157). detail...
Unknown unknown lung non-small cell carcinoma not applicable PRN1371 Preclinical - Pdx Actionable In a preclinical study, PRN1371 treatment resulted in tumor regression in PDX models of non-small cell lung cancer (Eu J Cancer 2014 Vol 50, Suppl 6:157). detail...
FGFR2 amp stomach cancer predicted - sensitive PRN1109 Preclinical - Cell line xenograft Actionable In a preclinical study, PRN1109 treatment resulted in tumor regression in gastric cancer cell line xenograft models harboring FGFR2 amplification (Eu J Cancer 2014 Vol 50, Suppl 6:157). detail...
Unknown unknown glioblastoma multiforme not applicable PRN1371 Preclinical - Pdx Actionable In a preclinical study, PRN1371 treatment resulted in tumor regression in PDX models of glioblastoma (Eu J Cancer 2014 Vol 50, Suppl 6:157). detail...