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Ref Type
Authors Joaquin Mateo, Johann Sebastian De Bono, Ramesh K. Ramanathan, Maryam B. Lustberg, Andrea Zivi, Dawn Basset, Matthew Ng, Anna-Mary Young, Michelle Garrett, Shaun Decordova, Florence I. Raynaud, Timothy Anthony Yap, Alexander A. Zukiwski, et al.
Title A first-in-human phase I trial of AR-12, a PDK-1 inhibitor, in patients with advanced solid tumors
Journal Journal of Clinical Oncology
Abstract Text J Clin Oncol 31, 2013 (suppl; abstr 2608)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable OSU03012 Phase I Actionable In a Phase I trial, OSU03012 (AR-12) treatment demonstrated safety and resulted in stable disease in 6% (2/30) of patients with advanced solid tumors, however, a new formulation was recommended due to limited absorption of the drug (J Clin Oncol 31, 2013 (suppl; abstr 2608)). detail...