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PMID | |
Authors | Ewa Jablonska et al. |
Title | A Novel Pan-PIM Kinase Inhibitor, SEL24-B489, Induces Apoptosis and Inhibits Proliferation of Diffuse Large B-Cell Lymphoma Cells through Inhibition of Protein Translation and Attenuation of Myc and NFkB Activity |
Journal | Blood |
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Date | |
URL | https://ash.confex.com/ash/2015/webprogram/Paper84427.html |
Abstract Text | Blood 126(23):706 December 2015 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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SEL24-B489 | SEL24-B489 | 1 | 1 |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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SEL24-B489 | SEL24|SEL 24|MEN1703|MEN-1703 | FLT3 Inhibitor 55 PIM Inhibitor (Pan) 9 | SEL24-B489 (MEN1703) is an inhibitor of PIM kinases 1, 2, 3, and FLT3, which may suppress cell growth and induce apoptosis (Blood 126 (23):706.December 2015, PMID: 29682194). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Unknown unknown | diffuse large B-cell lymphoma | not applicable | Ibrutinib + SEL24-B489 | Preclinical | Actionable | In a preclinical study, SEL24-B489 demonstrated a synergistic effect when combined with Ibruvica (ibrutinib) in diffuse large B-cell lymphoma cells in culture, resulting in cell growth inhibition ((Blood 126 (23):706.December 2015). | detail... |
Unknown unknown | diffuse large B-cell lymphoma | not applicable | SEL24-B489 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SEL24-B489 treatment induced apoptosis in diffuse large B-cell lymphoma cells in both culture and xenograft models (Blood 126 (23):706.December 2015). | detail... |