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|Authors||Arkenau H; Voskoboynik M; Infante J; Brenner A; Patel M; Borazanci E; Falchook G; Molife L; Molife L; Pelosof L; Jones S; Rubino C; McCulloch W; Zhukova-Harrill V; Kemble G; O'Farrell M; Burris H; Dean, Emma J|
|Title||Evidence of activity of a new mechanism of action (MoA): A first-in-human study of the first-in-class fatty acid synthase (FASN) inhibitor, TVB-2640, as monotherapy or in combination|
|Journal||Eur J Cancer|
|Abstract Text||2015 51 S724-S724 Eur J Cancer|
|Molecular Profile||Treatment Approach|
|Gene Name||Source||Synonyms||Protein Domains||Gene Description||Gene Role|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Gene||Variant||Impact||Protein Effect||Variant Description||Associated with drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||peritoneal serous adenocarcinoma||not applicable||Paclitaxel + TVB-2640||Case Reports/Case Series||Actionable||In a Phase I trial, TVB-2640 and Taxol (paclitaxel) combination treatment resulted in partial response in one patient with peritoneal serous carcinoma (2015 51 S724-S724 Eur J Cancer).||detail...|
|Unknown unknown||lung non-small cell carcinoma||not applicable||TVB-2640||Phase I||Actionable||In a Phase I study, TVB-2640 as a monotherapy or in combination with Taxol (paclitaxel) resulted in stable diseases for more than 16 weeks in 43% (3/7) of patients with non-small cell lung cancer (2015 51 S724-S724 Eur J Cancer).||detail...|
|Unknown unknown||triple-receptor negative breast cancer||not applicable||TVB-2640||Phase I||Actionable||In a Phase I clinical trial, TVB-2640 treatment resulted in stable disease for 20 weeks in one patient with triple-receptor negative breast cancer (2015 51 S724-S724 Eur J Cancer).||detail...|