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Ref Type
PMID
Authors Peter J. O'Dwyer, Kyriakos P. Papadopoulos, Anthony W. Tolcher, Ursina R. Teitelbaum, Kathleen Harlacker, Lon S. Smith, Davendra Sohal, Drew Warren Rasco, Muralidhar Beeram, Mariam Mehran, Manal Tawashi, Michel A. Drouin, James Wang, Marielle Fournel, Chr
Title MGCD265, a multitargeted oral tyrosine kinase receptor inhibitor of Met and VEGFR, in combination with erlotinib in patients with advanced solid tumors.
Journal J Clin Oncol
Vol
Issue
Date
URL http://meetinglibrary.asco.org/content/96526-114
Abstract Text J Clin Oncol 30, 2012 (suppl; abstr e13602)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown gastroesophageal junction adenocarcinoma not applicable Erlotinib + Glesatinib Phase I Actionable In a Phase I trial, 38% (3/8) of patients with gastroesophageal cancer remained on study for approximately 12-26 cycles with Glesatinib (MGCD265) and Tarceva (erlotinib) combination therapy (J Clin Oncol 30, 2012 (suppl; abstr e13602)). detail...
Unknown unknown Advanced Solid Tumor not applicable Erlotinib + Glesatinib Phase I Actionable In a Phase I trial, Glesatinib (MGCD265) and Tarceva (erlotinib) combination therapy demonstrated safety and preliminary clinical efficacy, resulted in partial response in 1 patient, and stable disease for 6 cycles or more in 16% (7/45) of patients with advanced solid tumors (J Clin Oncol 30, 2012 (suppl; abstr e13602)). detail...