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Authors | Natalya Bodyak, Alex Yurkovetskiy, Mao Yin, Dmitry Gumerov, Reddy Bollu, Patrick Conlon, Venu R. Gurijala, Dennis McGillicuddy, Cheri Stevenson, Elena Ter-Ovanesyan, Peter U. Park, Laura Poling, Winnie Lee, Michael DeVit, Dongmei Xiao, LiuLiang Qin et. al | ||||||||||||
Title | Discovery and preclinical development of a highly potent NaPi2b-targeted antibody-drug conjugate (ADC) with significant activity in patient-derived non-small cell lung cancer (NSCLC) xenograft models | ||||||||||||
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URL | http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=4017&sKey=43ef76fe-c845-4b4b-8531-601f2b1c2c32&cKey=132d0ba9-cd0a-4831-b61a-3bba3ae06518&mKey=1d10d749-4b6a-4ab3-bcd4-f80fb1922267 | ||||||||||||
Abstract Text | Proceedings of AACR, Vol 57, Apr 2016, Abstract # 1194 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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XMT-1536 | XMT1536|XMT 1536|Upifitamab Rilsodotin|Anti-NaPi2b ADC XMT-1536 | XMT-1536 is an anti-type II sodium-dependent potassium transporter (NaPi2b) antibody in conjugation with cytotoxic auristatin molecules, which delivers auristatin to tumor cells over expressing NaPi2b and results in tumor cell death (Proceedings of AACR, Vol 57, Apr 2016, Abstract # 1194). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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