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Ref Type
PMID
Authors Brent O'Carrigan, Maria Jose de Miguel Luken, Dionysios Papadatos-Pastos, Jessica Brown, Nina Tunariu, Raquel Perez Lopez, Mahesha Ganegoda, Ruth Riisnaes, Ines Figueiredo, Suzanne Carreira, Brian Hare, Fang Yang, Katherine McDermott et al
Title Phase I trial of a first-in-class ATR inhibitor VX-970 as monotherapy (mono) or in combination (combo) with carboplatin (CP) incorporating pharmacodynamics (PD) studies.
Journal J Clin Oncol
Vol
Issue
Date
URL http://abstracts.asco.org/176/AbstView_176_165738.html
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 2504)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM loss colorectal cancer sensitive Berzosertib Phase I Actionable In a Phase I trial, Berzosertib (VX-970) treatment resulted in complete response for more than 19 months in a colorectal cancer patient harboring ATM loss (J Clin Oncol 34, 2016 (suppl; abstr 2504)). detail...
Unknown unknown Advanced Solid Tumor not applicable Berzosertib Phase I Actionable In a Phase I trial, Berzosertib (VX-970) treatment resulted in complete response in 9% (1/11) and stable disease in 36% (4/11) of patients with advanced solid tumors (J Clin Oncol 34, 2016 (suppl; abstr 2504)). detail...