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Ref Type
Authors Crystal Shereen Denlinger, Maria Alsina Maqueda, David J. Watkins, Sun Jin Sym, Johanna C. Bendell, Se Hoon Park, Hendrik-Tobias Arkenau, Tanios S. Bekaii-Saab, Art J. Kudla, Charlotte Fenton McDonagh, Akos Gabor Czibere, Benoist Chibaudel et al
Title Randomized phase 2 study of paclitaxel (PTX), trastuzumab (T) with or without MM-111 in HER2 expressing gastroesophageal cancers (GEC).
Journal J Clin Oncol
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 4043)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 positive gastroesophageal junction adenocarcinoma no benefit MM-111 + Paclitaxel + Trastuzumab Phase II Actionable In a Phase II trial, Taxol (paclitaxel) and Herceptin (trastuzumab) treatment in combination with MM-111 did not improve progression free survival (9.6 weeks) and median overall survival (32.1 weeks) compared to without MM-111 (23.3 weeks, 56.1 weeks) in ERBB2 positive gastroesophageal junction cancer patients (J Clin Oncol 34, 2016 (suppl; abstr 4043)). detail...