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Ref Type
PMID
Authors Mansoor Raza Mirza, Christiane Ehlers Mortensen, Rene dePont Christensen, Louise Christoffersen, Mia Westergaard, Louisa Boufercha, Michael Birrer, Elisabeth Avall-Lundqvist, Line Bjorge, Johanna Unelma Maenpaa
Title A phase I study of bevacizumab in combination with niraparib in patients with platinum-sensitive epithelial ovarian cancer: The ENGOT-OV24/AVANOVA1 trial.
Journal J Clin Oncol
Vol
Issue
Date
URL http://abstracts.asco.org/176/AbstView_176_167216.html
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 5555)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown ovary epithelial cancer not applicable Bevacizumab + Niraparib Phase I Actionable In a Phase I trial, Avastin (bevacizumab) and Zejula (niraparib) combination treatment resulted in complete response in 8% (1/12), partial response in 33% (4/12), and a disease control rate of 91% in platinum-sensitive ovarian cancer patients (J Clin Oncol 34, 2016 (suppl; abstr 5555)). detail...