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Ref Type
PMID
Authors Rachid C. Baz, Kenneth H. Shain, Melissa Alsina, Jason Brayer, Tami Rashal, Jennifer L Cooksey, Joel G Turner, Jana Dawson, Daniel Sullivan
Title Phase I trial of the combination of selinexor (SEL), liposomal doxorubicin (DOX) and dexamethasone (Dex) for relapsed and refractory multiple myeloma (RRMM).
Journal J Clin Oncol
Vol
Issue
Date
URL http://abstracts.asco.org/176/AbstView_176_168723.html
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 8013)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown multiple myeloma not applicable Dexamethasone + Pegylated liposomal-doxorubicin + Selinexor Phase I Actionable In a Phase I trial, treatment with the combination of Selinexor (KPT-330), Doxil (pegylated liposomal doxorubicin), and Dexamethasone resulted in very good partial response in 20% (2/10), partial response in 20% (2/10), minimal response in 20% (2/10), and stable disease in 30% (3/10) of patients with relapsed or refractory multiple myeloma (J Clin Oncol 34, 2016 (suppl; abstr 8013)). detail...