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Ref Type | Journal Article |
PMID | (21969494) |
Authors | Buti S, Donini M, Sergio P, Garagnani L, Schirosi L, Passalacqua R, Rossi G |
Title | Impressive response with imatinib in a heavily pretreated patient with metastatic c-KIT mutated thymic carcinoma. |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology |
Vol | 29 |
Issue | 33 |
Date | 2011 Nov 20 |
URL | |
Abstract Text |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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KIT Y553N | thymic carcinoma | sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with metastatic thymic carcinoma harboring KIT Y553N demonstrated improved clinical performance and reduction in metastatic lesions following treatment with Gleevec (imatinib) (PMID: 21969494). | 21969494 |