Reference Detail

Ref Type Journal Article
PMID (21969494)
Authors Buti S, Donini M, Sergio P, Garagnani L, Schirosi L, Passalacqua R, Rossi G
Title Impressive response with imatinib in a heavily pretreated patient with metastatic c-KIT mutated thymic carcinoma.
Journal Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Vol 29
Issue 33
Date 2011 Nov 20
URL
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Therapy Description
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT Y553N thymic carcinoma sensitive Imatinib Clinical Study Actionable In a clinical case report, a patient with metastatic thymic carcinoma harboring KIT Y553N demonstrated improved clinical performance and reduction in metastatic lesions following treatment with Gleevec (imatinib) (PMID: 21969494). 21969494