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Ref Type
PMID
Authors Reinhard Dummer, Dirk Schadendorf, Paolo Antonio Ascierto, Ana Maria Arance Fernández, Caroline Dutriaux, Michele Maio, Piotr Rutkowski, Michele Del Vecchio, Ralf Gutzmer, Mario Mandalà, Luc Thomas, Ernesto Wasserman, James Ford, Marine Weill et al
Title Results of NEMO: A phase III trial of binimetinib (BINI) vs dacarbazine (DTIC) in NRAS-mutant cutaneous melanoma.
Journal J Clin Oncol
Vol
Issue
Date
URL http://meetinglibrary.asco.org/content/166136-176
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 9500)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS mutant skin melanoma sensitive Binimetinib Phase III Actionable In a Phase III trial, Binimetinib (MEK162) treatment resulted in improved progression free survival (2.8 months), objective response rate (15%, 40/269) and disease control rate (58%, 156/269) compared to Deticene (dacarbazine) (1.5 months, 7%, 25%, respectively) in NRAS-mutant cutaneous melanoma patients (J Clin Oncol 34, 2016 (suppl; abstr 9500)). detail...