Reference Detail

Ref Type
Authors Christophe Massard, Analia Azaro, Christophe Le Tourneau, Jean-Charles Soria, Marie Alt, Claire Smith, Ute Ohnmacht, Gerard Oakeley, Bharvin Patel, Eunice Yuen, Karim A. Benhadji, Jordi Rodon Ahnert
Title First-in-human study of LY3039478, a Notch signaling inhibitor in advanced or metastatic cancer
Journal Journal of Clinical Oncology
Abstract Text J Clin Oncol 33, 2015 (suppl; abstr 2533)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable LY3039478 Phase I Actionable In a Phase I trial, treatment with LY3039478 was well-tolerated and demonstrated some preliminary efficacy in patients with advanced solid tumors (J Clin Oncol 33, 2015 (suppl; abstr 2533)). detail...