Reference Detail

Ref Type
PMID
Authors Pamela T. Soliman, Shannon Neville Westin, David A Iglesias, Mark F. Munsell, Brian M. Slomovitz, Karen H. Lu, Robert L. Coleman
Title Phase II study of everolimus, letrozole, and metformin in women with advanced/recurrent endometrial cancer.
Journal J Clin Oncol
Vol
Issue
Date
URL http://meetinglibrary.asco.org/content/167204-176
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 5506)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown endometrial cancer not applicable Everolimus + Letrozole + Metformin Phase II Actionable In a Phase II trial, combination therapy consisted of Afinitor (everolimus), Femara (letrozole), and Glucophage (metformin) resulted in partial response in 29% (14/48) and stable disease in 38% (18/48) of patients with recurrent endometrioid endometrial cancer, the clinical benefit rate was not associated with KRAS mutation status in these patients (J Clin Oncol 34, 2016 (suppl; abstr 5506)). detail...