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Ref Type
Authors Andrew M. Evens, Fangxin Hong, Thomas Matthew Habermann, Ranjana H. Advani, Randy D. Gascoyne, Thomas E. Witzig, Andrew Quon, Lynne I. Wagner, Stephen Maxted Ansell, Adam Matthew Petrich, Julie E. Chang, Timothy E. O'Brien, Puneet S. Cheema et al
Title Effect of bortezomib on complete remission (CR) rate when added to bendamustine-rituximab (BR) in previously untreated high-risk (HR) follicular lymphoma (FL): A randomized phase II trial of the ECOG-ACRIN Cancer Research Group (E2408).
Journal J Clin Oncol
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 7507)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown follicular lymphoma not applicable Bendamustine + Bortezomib + Rituximab Phase II Actionable In a Phase II trial, addition of Velcade (Bortezomib) to Bendamustine and Rituxan (rituximab) combination therapy resulted in improved complete response (74%, 63/85) compared to without Velcade (Bortezomib) (58%, 80/137) in high risk follicular lymphoma patients (J Clin Oncol 34, 2016 (suppl; abstr 7507)). detail...