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Ref Type
Authors Andrea B. Apolo, Howard L. Parnes, Deneise C Francis, Lisa M Cordes, Marilise Berninger, Elizabeth Lamping, Rene Costello, Jane B. Trepel, Maria J Merino, Les Folio, Maria Liza Lindenberg, William Douglas Figg, Seth M. Steinberg, John Joseph Wright et al
Title A phase II study of cabozantinib in patients (pts) with relapsed or refractory metastatic urothelial carcinoma (mUC).
Journal J Clin Oncol
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 4534)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown transitional cell carcinoma not applicable Cabozantinib Phase II Actionable In a Phase II trial, Cometriq (cabozantinib) treatment resulted in complete response in 2% (1/41), partial response in 17% (7/41), stable disease in 44% (18/41) of urothelial carcinoma patients, with a median progression-free survival of 3.7 months and median overall survival of 8.2 months (J Clin Oncol 34, 2016 (suppl; abstr 4534)). detail...