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Ref Type
Authors Erika Paige Hamilton, Judy Sing-Zan Wang, Gerald Falchook, Suzanne Fields Jones, Carl Cook, Ganesh Mugundu, Philip John Jewsbury, Mark J. O'Connor, Andrew J Pierce, Bob T. Li, Amit M. Oza, Jeffrey R. Infante, Howard A. Burris, David R. Spigel
Title A phase Ib study of AZD1775 and olaparib combination in patients with refractory solid tumors.
Journal J Clin Oncol
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 5562)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Adavosertib + Olaparib Phase Ib/II Actionable In a Phase Ib trial, Adavosertib (MK-1775) and Lynparza (olaparib) combination therapy resulted in partial response in 17% (1/6) and stable disease in 67% (4/6) of patients with advanced solid tumors (J Clin Oncol 34, 2016 (suppl; abstr 5562)). detail...