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Ref Type
PMID
Authors Se-Hoon Lee, June-Koo Lee, Myung-Ju Ahn, Dong-Wan Kim, Jong-Mu Sun, Bhumsuk Keam, Tae Min Kim, Dae Seog Heo, Jin Seok Ahn, Yoon-La Choi, Hae-Sook Min, Yoon-Kyung Jeon, Keunchil Park
Title A phase II study of vandetanib in patients with non-small cell lung cancer harboring RET rearrangement.
Journal J Clin Oncol
Vol
Issue
Date
URL http://meetinglibrary.asco.org/content/166941-176
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 9013)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET fusion lung non-small cell carcinoma sensitive Vandetanib Phase II Actionable In a Phase II trial, Caprelsa (vandetanib) treatment resulted in partial remission in 17% (3/18) and stable disease in 44% (8/18) of non-small cell lung adenocarcinoma patients harboring RET fusions (J Clin Oncol 34, 2016 (suppl; abstr 9013)). detail...