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Authors J. Bauml, T. Y. Seiwert, D. G. Pfister, F. P. Worden, S. V. Liu, J. Gilbert, N. F. Saba, J. Weiss, L. J. Wirth, A. Sukari, Hyunseok Kang, M. K. Gibson, E. Massarelli, S. Francis Powell, A. Meister, X. Shu, J. D. Cheng, R. I. Haddad
Title Preliminary results from KEYNOTE-055: Pembrolizumab after platinum and cetuximab failure in head and neck squamous cell carcinoma (HNSCC).
Journal J Clin Oncol 34, 2016 (suppl; abstr 6011)
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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown head and neck squamous cell carcinoma not applicable Pembrolizumab FDA approved Actionable In a Phase Ib trial (KEYNOTE-012) that supported FDA approval, treatment with Keytruda (pembrolizumab) resulted in an objective response rate of 18% (24/132; 4 complete response, 20 partial response) in patients with recurrent and/or metastatic head and neck squamous cell carcinoma (PMID: 27247226; NCT01848834). detail... detail... 27247226