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Ref Type
Authors Alex A. Adjei, Grace K. Dy, Yujie Zhao, Wen Wee Ma, Mateusz Opyrchal, Hatoon Bakhribah, Sandra M Jacob, Corrie O'Hara, Askia Dozier, Natasa Cmiljanovic, Barbara Todaro, William E. Brady, Debora Schmitz, Sasa Dimitrijevic
Title A phase 1 study of the PI3K/mTOR inhibitor PQR309 evaluating safety, pharmacokinetics (PK) and pharmacodynamics (PD) in patients (pts) with advanced solid tumors.
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 2560)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable PQR309 Phase I Actionable In a Phase I trial, PQR309 demonstrated safety and preliminary efficacy in patients with advanced solid tumors (J Clin Oncol 34, 2016 (suppl; abstr 2560)). detail...