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Ref Type
PMID
Authors T.K. Choueiri, S. Halabi, B. Sanford, O. Hahn, M.D. Michaelson, M. Walsh, T. Olencki, J. Picus, E.J. Small, S. Dakhil, D. George, M.J. Morris
Title CABOzantinib versus SUNitinib (CABOSUN) as initial targeted therapy for patients with metastatic renal cell carcinoma (mRCC) of poor and intermediate risk groups: Results from ALLIANCE A031203 trial
Journal
Vol
Issue
Date
URL http://www.esmo.org/Conferences/ESMO-2016-Congress/Press-Media/Cabozantinib-Improves-Progression-free-Survival-in-Metastatic-Renal-Cell-Carcinoma
Abstract Text ESMO 2016 Congress in Copenhagen, Abstract LBA30_PR

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown renal cell carcinoma not applicable Cabozantinib Phase II Actionable In a Phase II trial, Cabometyx (cabozantinib) treatment demonstrated improved median progression-free survival (8.2 vs 5.6 months) and overall response rate (46% vs 18%) over Sutent (sunitinib) in untreated patients with metastatic renal cell carcinoma (ESMO 2016 Congress in Copenhagen, Abstract LBA30_PR). detail... detail...