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Ref Type
Authors Margaret von Mehren, Eric Daniel Tetzlaff, Meghan Macaraeg, Jeremy Davis, Vartika Agarwal, Abhijit Ramachandran, Michael C. Heinrich
Title Dose escalating study of crenolanib besylate in advanced GIST patients with PDGFRA D842V activating mutations.
Journal J Clin Oncol 34, 2016 (suppl; abstr 11010)
Abstract Text


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PDGFRA D842V gastrointestinal stromal tumor sensitive Crenolanib Phase Ib/II Actionable In a Phase I/II trial, treatment with Crenolanib (CP-868596) resulted in a clinical benefit rate of 31% (5/16) in gastronintestinal stromal tumor patients harboring PDGFRA D842V, with partial response in 2/16 and stable disease in 3/16 patients (J Clin Oncol 34, 2016 (suppl; abstr 11010)). detail...