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Ref Type
PMID
Authors Daniela Bota, Annick Desjardins, Warren Mason, Howard Fine, Santosh Kesari, Steven D. Reich, Anshu Vashishtha, Nancy Levin and Mohit Trikha
Title MARIZOMIB (MRZ) WITH BEVACIZUMAB (BEV) IN WHO GRADE IV MALIGNANT GLIOMA (G4 MG): FULL ENROLLMENT RESULTS FROM THE PHASE 1, MULTICENTER, OPEN-LABEL STUDY
Journal Neuro Oncol
Vol
Issue
Date
URL http://neuro-oncology.oxfordjournals.org/content/18/suppl_6/vi13.1.abstract?sid=ad844053-14c2-462b-b5b1-989be93a747b
Abstract Text Neuro Oncol (2016) 18 (suppl 6): vi13.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown malignant glioma not applicable Bevacizumab + Marizomib Phase I Actionable In a Phase I trial, Marizomib (NPI-0052) and Avastin (bevacizumab) combination therapy resulted in complete target lesion response in 14% (5/36), partial response in 25% (9/36), and stable disease in 31% (11/36) of Avastin (bevacizumab)-naive patients with WHO grade IV malignant giloma (Neuro Oncol (2016) 18 (suppl 6): vi13.). detail...