Reference Detail

Ref Type
Authors Normand Beaulieu, Isabelle Dupont, Claire Bonfils, Marja Dubay, Hélène Ste-Croix, Lubo Isakovic, Stephen Claridge, Oscar Saavedra, Franck Raeppel, Stephane Raeppel, Michael Mannion, Arkadii Vaisburg, Jeffrey M. Besterman and Christiane R. Maroun
Title Abstract 3609: MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, potently inhibits clinically relevant Met mutants
Journal Cancer Research
Abstract Text AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3609


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MET act mut Advanced Solid Tumor sensitive Glesatinib Preclinical Actionable In a preclinical study, cells harboring MET activating mutations demonstrated sensitivity to treatment with Glesatinib (MGCD265) in cell-based assays (AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3609). detail...