Reference Detail

Ref Type
PMID
Authors
Title A FIRST IN HUMAN, DOSE ESCALATION TRIAL OF MSC2363318A - A DUAL P70S6K/AKT INHIBITOR, FOR PATIENTS WITH ADVANCED MALIGNANCIES
Journal Annals of Oncology
Vol
Issue
Date
URL http://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/annonc/26/suppl_2/10.1093_annonc_mdv094.1/3/mdv094.1.pdf?Expires=1485612028&Signature=JoQKC8sVU14rOLnGDs5B85m-vEzduY5hMhBWvxZjYnC8qeS
Abstract Text Ann. Oncol. 26 (Suppl 2): ii25-ii27, 2015

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable M2698 Phase I Actionable In a Phase I trial, M2698 (MSC2363318A) demonstrated safety and preliminary efficacy in a variety of advanced solid tumor patients (Ann. Oncol. 26 (Suppl 2): ii25-ii27, 2015). detail...