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Ref Type
Authors H. Schmoll, B. Garlipp, C. Junghanss, M. Leithaeuser, A. Vogel, M. Schaefers, U. Kaiser, H. Hoeffkes, A. Florschütz, J. Rüssel, S. Kanzler, T. Edelmann, H. Forstbauer, T. Goehler, C. Hannig, B. Hildebrandt, J. Steighardt, F. M. Meinert, F. Cygon, A. Stein
Title CHARTA: FOLFOX+bevacizumab +/- irinotecan in advanced colorectal cancer (CRC)—Final results of the randomized phase II trial of the AIO (KRK 0209).
Abstract Text J Clin Oncol 35, 2017 (suppl 4S; abstract 658)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colorectal cancer not applicable Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Phase II Actionable In a Phase II trial, the combination of Avastin (bevacizumab) plus FOLFOXIRI chemotherapy was well-tolerated and resulted in improved progression-free survival compared to Avastin (bevacizumab) plus FOLFOX in colorectal cancer patients (J Clin Oncol 35, 2017 (suppl 4S; abstract 658)). detail...