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Authors | Sang Hyun Lee, Xuesong Mike Liu, Melody Diamond, Valerie Dostalik, Margaret Favata, Chunhong He, Liangxing Wu, Richard Wynn, Wenqing Yao, Gregory Hollis, Reid Huber, Peggy Scherle and Bruce Ruggeri | ||||||||||||
Title | The evaluation of INCB059872, an FAD-directed inhibitor of LSD1, in preclinical models of human small cell lung cancer | ||||||||||||
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URL | http://cancerres.aacrjournals.org/content/76/14_Supplement/4704 | ||||||||||||
Abstract Text | Cancer Res 2016;76(14 Suppl):Abstract nr 4704 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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INCB059872 | INCB059872 | 0 | 2 |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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INCB059872 | KDM1A Inhibitor 15 | INCB059872 is a specific inhibitor of lysine specific demethylase 1 (KDM1A, LSD1) that increases tumor-suppressor gene expression through enhancing Histone H3 methylation, leading to anti-tumor effects (Cancer Res 2016;76(14 Suppl):Abstract nr 4704, PMID: 32422235). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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