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Ref Type Journal Article
PMID (8913270)
Authors Qiao L, Koutsos M, Tsai LL, Kozoni V, Guzman J, Shiff SJ, Rigas B
Title Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells.
Journal Vol Issue Date Pages Journal Short Title
Cancer letters 107 1 1996 Oct 01 83-9 Cancer Lett
URL
Abstract Text Staurosporine (ST), a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on the proliferation of HT-29 colon adenocarcinoma cells; PKC is associated with increased colon cell proliferation. ST inhibited cell proliferation in a time- and concentration-dependent manner by up to 90%. It also blocked the G2/M phase of the cell cycle and induced classical apoptosis (sub-diploid peak on flow cytometry, DNA ladder, and typical morphological changes). The kinetics of these changes suggest that low ST concentrations (2-20 nM) may act via a different mechanism from higher (100-1000 nM) ones. The role of ST, which is currently evaluated as an antitumor agent, in colon cancer requires further evaluation.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Staurosporine Staurosporine 0 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
Staurosporine CGP-39360|AM-2282 PAK1 Inhibitor 11 PKC Inhibitor (Pan) 11 Staurosporine (CGP-39360) is an alkaloid pan-protein kinase C (PKC) inhibitor, with activity against several additional protein kinases, including PAK1 (PMID: 32863957), which may result in increased apoptosis and decreased tumor cell growth (PMID: 3457562, PMID: 8529658, PMID: 8913270).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References