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Ref Type
PMID
Authors Diana I. Albu, Jiayi Wu, Kuan-chung Huang, Renee Wright-Michaud, Shanqin Xu, Galina Kuznetsov, Xingfeng Bao and Mary Woodall-Jappe
Title Abstract B198: Pharmacological profile of the PGE2 EP4 receptor antagonist E7046
URL http://mct.aacrjournals.org/content/14/12_Supplement_2/B198.short
Abstract Text Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B198

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
E7046 E7046 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
E7046 AN0025|E-7046|E 7046 AN0025 (E7046) is a small molecule inhibitor of E2 receptor type 4 (EP4), which may result in antitumor activity including inhibition of cell proliferation and reduced tumor growth (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B198, PMID: 32554609).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References