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Ref Type
Authors Diana I. Albu, Jiayi Wu, Kuan-chung Huang, Renee Wright-Michaud, Shanqin Xu, Galina Kuznetsov, Xingfeng Bao and Mary Woodall-Jappe
Title Abstract B198: Pharmacological profile of the PGE2 EP4 receptor antagonist E7046
Journal Molecular Cancer Therapeutics
Abstract Text Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B198


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
E7046 AN0025|E-7046|E 7046 AN0025 (E7046) is a small molecule inhibitor of E2 receptor type 4 (EP4), which may result in antitumor activity including inhibition of cell proliferation and reduced tumor growth (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B198, PMID: 32554609).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colon cancer not applicable E7046 Preclinical Actionable In a preclinical study, a colon cancer mouse model harboring an APC mutation demonstrated decreased polyp formation and decreased cell proliferation when treated with the EP4 antagonist, E7046 (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B198). detail...