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Ref Type
PMID
Authors S. Hu, N. Ke, Y. Ren, S. Miljovska, N. Rajagopal, M. McKeown, D. Orlando, K. Sprott, Y.J. Choi, E. Olson, C.C. Fritz
Title SY-1365, a potent and selective CDK7 inhibitor, exhibits promising anti-tumor activity in multiple preclinical models of aggressive solid tumors
Journal Proceedings of the AACR
Vol
Issue
Date
URL https://books.google.com/books?id=4UFUDgAAQBAJ&pg=PT1269&lpg=PT1269&dq=SY-1365+aacr&source=bl&ots=qSIk2T1yGY&sig=KtZ3HYzvtHo8njvplLeHoPoXTFg&hl=en&sa=X&ved=0ahUKEwim2sfivPzTAhUY0GMKHdZ3CxMQ6AEIPjAE#v=
Abstract Text Proceedings of the AACR, Vol 58, April 2017, Abstract # 1151

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
SY-1365 SY-1365 2 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable SY-1365 + Venetoclax Preclinical - Cell culture Actionable In a preclinical study, SY-1365 and Venclexta (venetoclax) synergistically induced apoptosis in acute myeloid leukemia cells in culture (Proceedings of the AACR, Vol 58, April 2017, Abstract # 1151). detail...
Unknown unknown triple-receptor negative breast cancer not applicable SY-1365 Preclinical - Pdx & cell culture Actionable In a preclinical study, SY-1365 induced rapid apoptosis in triple-receptor negative breast cancer cells in culture, and resulted in tumor growth inhibition in patient-derived xenograft models (Proceedings of the AACR, Vol 58, April 2017, Abstract # 1151). detail...
Unknown unknown Advanced Solid Tumor not applicable SY-1365 Preclinical - Cell culture Actionable In a preclinical study, SY-1365 induced rapid apoptosis in a panel of solid tumor cell lines in culture, including breast, ovarian, colorectal, and lung cancer cells (Proceedings of the AACR, Vol 58, April 2017, Abstract # 1151). detail...
Unknown unknown triple-receptor negative breast cancer not applicable Niraparib + SY-1365 Preclinical - Cell culture Actionable In a preclinical study, SY-1365 and Zejula (niraparib) synergistically induced apoptosis in triple-receptor negative breast cancer cells in culture (Proceedings of the AACR, Vol 58, April 2017, Abstract # 1151). detail...