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Ref Type
Authors X. Bao, D.I. Albu, K.C. Huang, J. Wu, N. Twine, K. Nomoto, M. Woodall-Jappe, O. Ataman
Title Combination of a Novel EP4 Antagonist E7046 and Radiation Therapy Promotes Anti-tumor Immune Response and Tumor Rejection in Preclinical Tumor Models
Journal International Journal of Radiation Oncology
Abstract Text International Journal of Rad Onc, 2016, 96;2, S128


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colon cancer not applicable E7046 + Radiotherapy Preclinical Actionable In a preclinical study, the combination treatment of E7046 and radiotherapy resulted in 9 out of 12 tumor free colon cancer mouse models and increased the number of T-cells infiltrating the tumor (International Journal of Rad Onc, 2016, 96;2, S128). detail...
Unknown unknown breast cancer not applicable E7046 + Radiotherapy Preclinical Actionable In a preclinical study, a breast cancer mouse model demonstrated greater inhibition of tumor growth and improved survival when treated with a combination of E7046 and radiotherapy compared to either agent alone (International Journal of Rad Onc, 2016, 96;2, S128). detail...