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PMID
Authors Jacob L. Houghton, Ryan Lanning, Dayla Abdel-atti,Toni Jun, Christine M. Kearns, Michael Schlosser, Wolfgang Scholz, Jason S. Lewis, Paul W. Maffuid
Title Preclinical development of MVT-1075 as radioimmunotherapy for pancreatic cancer and other CA19-9 positive malignancies
Journal AACR journal
Vol
Issue
Date
URL http://www.aacr.org/Meetings/Pages/MeetingDetail.aspx?EventItemID=105&DetailItemID=539#.WR9AdvMo9Qo
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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
MVT-1075 MVT-1075 1 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
MVT-1075 MVT-1075 is a radiolabeled IgG1 antibody that binds to the sialyl Lewis A epitope of CA19-9 and is conjugated to a bifunctional chelator, which may result in tumor growth inhibition and tumor regression (AACR 2017, Abstract nr5204).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown pancreatic cancer not applicable MVT-1075 Preclinical - Cell line xenograft Actionable In a preclinical study, a pancreatic cancer xenograft model demonstrated tumor growth inhibition and tumor regression by 50% when treated with MVT-1075 (AACR 2017, Abstract #5204). detail...