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Ref Type
Authors D Hyman, S Piha-Paul, C Saura, C Arteaga, I Mayer, G Shapiro, S Loi, A Lalani, F Xu, R Cutler, A Butturini, R Bryce, F Meric-Bernstam, J Baselga and D Solit
Title Neratinib + fulvestrant in ERBB2-mutant, HER2–non-amplified, estrogen receptor (ER)-positive, metastatic breast cancer (MBC): Preliminary analysis from the phase II SUMMIT trial
Journal Cancer Res
Abstract Text Cancer Res 2017;77(4 Suppl):Abstract nr PD2-08


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 mutant Her2-receptor positive breast cancer sensitive Neratinib Phase II Actionable In a Phase II trial, Nerlynx (neratinib) treatment resulted in complete response in 12.5% (3/24) and partial response in 20.8% (5/24) of ERBB2 (HER2) mutant but not amplified breast cancer patients (Cancer Res 2017;77(4 Suppl):Abstract nr PD2-08). detail...