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Authors | E. Lew, C. Walsh, E. Martin, A. Albert, G.G. Li, Y. Yokoyama | ||||||||||||
Title | Immuno-oncologic efficacy of RXDX-106, a selective, TAM family small molecule kinase inhibitor | ||||||||||||
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URL | http://www.sciencedirect.com/science/article/pii/S0959804916326739?via%3Dihub | ||||||||||||
Abstract Text | European Journal of Cancer, Vol 69, Supplement 1, December 2016, Page S31 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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RXDX-106 | CEP-40783|CEP40783|CEP 40783|RXDX106|RXDX 106 | AXL Inhibitor 29 MERTK Inhibitor 13 MET Inhibitor 58 TYRO3 Inhibitor 8 | RXDX-106 (CEP-40783) is a small molecule inhibitor of TAM family kinases (Axl, Mertk, and Tyro3) and Met that promotes anti-tumor immune response, resulting in tumor growth inhibition (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31, PMID: 30501104, PMID: 30723115). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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