Reference Detail

Ref Type
Authors Marc Oliver Salzberg, Pierre Triozzi, Mitra Kooshki, Angela Tatiana Alistar, Rhonda Lynn Bitting, Joyce Fenstermaker, Guenther Lametschwandtner, Hans Loibner
Title Adoptive cellular immunotherapy with APN401, autologous Cbl-b-silenced peripheral blood mononuclear cells, in patients with solid tumors.
Abstract Text


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
APN401 APN401 1 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
APN401 APN401 is composed of autologous peripheral blood mononuclear cells in which Cbl-b has been silenced with siRNA, which potentially results in increased anti-tumor immune response upon infusion (J Clin Oncol 34, 2016 (suppl; abstr e14541)).
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable APN401 Phase I Actionable In a Phase I trial, APN401 infusion demonstrated safety in patients with advanced solid tumors, and resulted in stable disease in two patients with pancreatic cancer and one patient with with colorectal cancer (J Clin Oncol 34, 2016 (suppl; abstr e14541)). detail...