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Authors | Marc Oliver Salzberg, Pierre Triozzi, Mitra Kooshki, Angela Tatiana Alistar, Rhonda Lynn Bitting, Joyce Fenstermaker, Guenther Lametschwandtner, Hans Loibner | ||||||||||||
Title | Adoptive cellular immunotherapy with APN401, autologous Cbl-b-silenced peripheral blood mononuclear cells, in patients with solid tumors. | ||||||||||||
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URL | http://meetinglibrary.asco.org/content/170952-176 | ||||||||||||
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Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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APN401 | APN401 is composed of autologous peripheral blood mononuclear cells in which Cbl-b has been silenced with siRNA, which potentially results in increased anti-tumor immune response upon infusion (J Clin Oncol 34, 2016 (suppl; abstr e14541)). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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