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Ref Type
PMID
Authors R. S. Meehan, A. P. Chen, G. Helen O'Sullivan C., J. M. Collins, S.Kummar, L. Anderson, K. Ishii, J. Zlott, L. Rubinstein, Y. Horneffer, L. Juwara, W. Jeong, N. Takebe, R. J. Kinders, R. E. Parchment, J. H. Doroshow
Title A phase 1 trial of TRC102 (methoxyamine HCl) with temozolomide (TMZ) in patients with solid tumors and lymphomas.
URL http://meetinglibrary.asco.org/content/168775-176
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 2556)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
TRC102 TRC102 0 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
TRC102 Methoxyamine|TRC-102 TRC102 (Methoxyamine) inhibits the base excision repair pathway, potentially resulting in increased sensitivity to chemotherapeutic agents and anti-tumor activity (J Clin Oncol 34, 2016 (suppl; abstr 2556), PMID: 23054206, PMID: 32556884).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References