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Ref Type
Authors Carlos Alberto Gomez-Roca, Valentina Boni, Victor Moreno, John Charles Morris, Jean-Pierre Delord, Emiliano Calvo, Kyriakos P. Papadopoulos, Olivier Rixe, Patrick Cohen, Alexia Tellier, Samira Ziti-Ljajic, Anthony W. Tolcher
Title A phase I study of SAR566658, an anti CA6-antibody drug conjugate (ADC), in patients (Pts) with CA6-positive advanced solid tumors (STs)(NCT01156870).
Journal J Clin Oncol
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 2511)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
SAR566658 SAR566658 is a monoclonal antibody against CA6 in conjugation with maytansinoid, which may deliver targeted cytotoxicity to MUC-1 over expressing tumor cells (J Clin Oncol 34, 2016 (suppl; abstr 2511).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable SAR566658 Phase I Actionable In a phase I trial, SAR566658 treatment resulted in complete response in 1% (1/114), partial response in 7% (8/114), and stable disease in 39% (44/114) of patients with advanced solid tumors (J Clin Oncol 34, 2016 (suppl; abstr 2511)). detail...