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Ref Type
PMID
Authors Carlos Alberto Gomez-Roca, Valentina Boni, Victor Moreno, John Charles Morris, Jean-Pierre Delord, Emiliano Calvo, Kyriakos P. Papadopoulos, Olivier Rixe, Patrick Cohen, Alexia Tellier, Samira Ziti-Ljajic, Anthony W. Tolcher
Title A phase I study of SAR566658, an anti CA6-antibody drug conjugate (ADC), in patients (Pts) with CA6-positive advanced solid tumors (STs)(NCT01156870).
URL http://meetinglibrary.asco.org/record/125293/abstract
Abstract Text J Clin Oncol 34, 2016 (suppl; abstr 2511)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
SAR566658 SAR566658 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
SAR566658 SAR-566658 SAR566658 is a monoclonal antibody against CA6 in conjugation with maytansinoid, which may deliver targeted cytotoxicity to MUC-1 over expressing tumor cells (J Clin Oncol 34, 2016 (suppl; abstr 2511), PMID: 32451330).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References