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Ref Type
PMID
Authors M. Ng, D. SP Tan, V. Subbiah, C. D. Weekes, V. Teneggi, V. Diermayr, K. Ethirajulu, P. Yeo, D. Chen, S. Blanchard, R. Nellore, B. Hwa Gan, M. Yasin, Lay Hoon Lee, May Ann Lee, Jeffrey Hill, Babita Madan, David Virshup, Alex Matter
Title First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours
Journal
Vol
Issue
Date
URL http://abstracts.asco.org/199/AbstView_199_181737.html
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr 2584)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable ETC-159 Phase I Actionable In a Phase I trial, treatment with ETC-159 was well-tolerated, decreased Wnt signaling, and resulted in stable disease in 2 out of 16 treated patients with advanced solid tumors (J Clin Oncol 35, 2017 (suppl; abstr 2584)). detail...