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Ref Type
Authors H. A. Burris, M. S. Gordon, M. D. Hellmann, P. LoRusso, L. A. Emens, F. S. Hodi, C. H. Lieu, J. R. Infante, F. Yung-Chin Tsai, J. P. Eder, J.M. Cleary, D. Jelovac, A. L. Tsuhako, L. Mueller, R. Lin, K. Morrissey, S. Mahrus, R Morley, A. Pirzkall, S. Davis
Title A phase Ib dose escalation study of combined inhibition of IDO1 (GDC-0919) and PD-L1 (atezolizumab) in patients (pts) with locally advanced or metastatic solid tumors.
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr 105)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Atezolizumab + GDC-0919 Phase I Actionable In a Phase I trial, treatment with GDC-0919 and Tecentriq (atezolizumab) in combination was well-tolerated and demonstrated preliminary anti-tumor activity in patients with advanced solid tumors, with partial response in 9% (4/45) and stable disease in 24% (11/45) of patients (J Clin Oncol 35, 2017 (suppl; abstr 105)). detail...