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PMID | |
Authors | RM Glasspool, SP Blagden, M Lockley, J Paul, C Hopkins, F Thomson, J Brown, R Fernandes, N Douglas, C Pou, A Hanif, C Campbell, PS Multani, T Tucker, IA McNeish, TRJ Evans |
Title | A phase I trial of the oral hedgehog inhibitor taladegib (LY2940680) in combination with weekly paclitaxel in patients with advanced, solid tumours. |
Journal | J Clin Oncol |
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Date | |
URL | http://abstracts.asco.org/199/AbstView_199_183751.html |
Abstract Text | J Clin Oncol 35, 2017 (suppl; abstr 2594) |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Unknown unknown | Advanced Solid Tumor | not applicable | Paclitaxel + Taladegib | Phase I | Actionable | In a Phase I trial, combination of Taladegib and Taxol (paclitaxel) treatment demonstrated safety and preliminary efficacy, resulted in partial response in 3 patients with advanced solid tumors (J Clin Oncol 35, 2017 (suppl; abstr 2594)). | detail... |