Reference Detail

Ref Type
PMID
Authors N Yanagitani, A Horiike, S Kitazono, F Ohyanagi, S Kondo, A Shimomura, Y Fujiwara, T Doi, Y Kuboki, A Kawazoe, K Shitara, I Ohno, U Banerji, R Sundar, S Ohkubo, JM Huang, M Nishio, N Yamamoto
Title First-in-human phase I study of an oral HSP90 inhibitor, TAS-116, in advanced solid tumors.
Journal J Clin Oncol
Vol
Issue
Date
URL http://abstracts.asco.org/199/AbstView_199_186280.html
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr 2546)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown gastrointestinal stromal tumor not applicable TAS-116 Phase I Actionable In a Phase I trial, TAS-116 treatment resulted in partial response in a patient with gastrointestinal stromal tumor (J Clin Oncol 35, 2017 (suppl; abstr 2546)). detail...
Unknown unknown non-small cell lung carcinoma not applicable TAS-116 Phase I Actionable In a Phase I trial, TAS-116 treatment resulted in partial response in 2 patients with non-small cell lung carcinoma (J Clin Oncol 35, 2017 (suppl; abstr 2546)). detail...