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Ref Type
Authors Aaron Richard Hansen, Geoffrey Shapiro, Khanh T Do, Rajiv Kumar, Juan Martin-Liberal, Celestia S. Higano, Kari Braun Wisinski, Emma Jane Dean, Elisabeth I. Heath, Dana E. Rathkopf, Mark David Linch, Simon T Barry, Wolfram Brugger, Elza De Bruin, et al.
Title A first in human phase I study of AZD8186, a potent and selective inhibitor of PI3K in patients with advanced solid tumours as monotherapy and in combination with the dual mTORC1/2 inhibitor vistusertib (AZD2014) or abiraterone acetate
Journal Journal of Clinical Oncology
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr 2570)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown prostate cancer not applicable AZD8186 + Vistusertib Phase I Actionable In a Phase I trial, the combination of AZD8186 and Vistusertib (AZD2014) resulted in a partial response in a patient with castration resistant prostate cancer (J Clin Oncol 35, 2017 (suppl; abstr 2570)). detail...