Reference Detail

Ref Type
Authors Mark van Bussel, Morten Mau-Soerensen, Lars Damstrup, Dorte Nielsen, Henk M.W. Verheul, Philippe Georges Aftimos, Maja J. De Jonge, Karin Berghoff, Jan H.M. Schellens
Title A multicenter phase I trial of the DNA-dependent protein kinase (DNA-PK) inhibitor M3814 in patients with solid tumors.
Abstract Text J Clin Oncol 35, 2017 (suppl; abstr 2556)


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor no benefit MSC2490484A Phase I Actionable In a Phase I trial, MSC2490484A (M3814) demonstrated safety, but limited clinical activity, in patients with solid tumors (J Clin Oncol 35, 2017 (suppl; abstr 2556)). detail...