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Ref Type
Authors Craig C Hofmeister, Jesus G. Berdeja, David H. Vesole, Attaya Suvannasankha, Tracy Parrott and Rafat Abonour
Title TG02, an Oral CDK9-Inhibitor, in Combination with Carfilzomib Demonstrated Objective Responses in Carfilzomib Refractory Multiple Myeloma Patients
Journal Blood
Abstract Text Blood 2015 126:3052


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown multiple myeloma not applicable Carfilzomib + Zotiraciclib Phase I Actionable In a Phase I trial, Zotiraciclib (TG02) in combination with Kyprolis (carfilzomib) resulted in an overall response rate of 27% (3/11) and durable stable disease in 27% (3/11) of multiple myeloma patients (Blood 2015 126:3052). detail...