Reference Detail

Ref Type
PMID
Authors Jeff Hsu, Yujun Huang, Chun-Te Chen, Jun Chen, Mint Sirisawad and Betty Y. Chang
Title Abstract 2321: Ibrutinib enhances antitumor activity in solid tumors when combined with checkpoint inhibitors
Journal Cancer Research
Vol
Issue
Date
URL http://cancerres.aacrjournals.org/content/76/14_Supplement/2321
Abstract Text Cancer Res 2016;76(14 Suppl):Abstract nr 2321

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colorectal cancer not applicable Ibrutinib + unspecified CTLA4 antibody Preclinical Actionable In a preclinical study, the combination of Imbruvica (ibrutinib) and an anti-CTLA4 antibody resulted in complete tumor regression in colorectal cancer mouse models (Cancer Res 2016;76(14 Suppl):Abstract nr 2321). detail...