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Ref Type
Authors A.M. Tsimberidou, C. Verschraegen, A. Weise, J. Sarantopoulos, G. Lopes, J. Nemunaitis, A. Victor, J. Shaw, R. Kaleta, R. Kurzrock
Title Phase I dose escalation study of M2698, a p70S6K/AKT inhibitor, in patients with advanced cancer
Journal Ann Oncol
Abstract Text Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 370PD


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable M2698 Phase I Actionable In a Phase I trial, M2698 (MSC2363318A) demonstrated safety and preliminary efficacy, with 19% (6/32) of advanced solid tumor patients remained on treatment for more than 180 days (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 370PD; NCT01971515). detail...