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PMID
Authors Janice Chen, Christopher L. Brooks, Peter McDonald, Jonathan D. Schwartz, Keiichi Sakakibara, Naoya Saito...Takuji Sato, Takumi Kawabe, Eric Keith Rowinsky
Title Preclinical activity of SL-801, a reversible inhibitor of Exportin-1 (XPO1)/Chromosome Region Maintenance-1 (CRM1) in solid and hematologic cancers
Journal Journal of Clinical Oncology
Vol
Issue
Date
URL http://ascopubs.org/doi/abs/10.1200/jco.2015.33.15_suppl.e13543
Abstract Text Journal of Clinical Oncology 33, no. 15_suppl

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
SL-801 SL-801 1 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
SL-801 SL-801 is a small molecule inhibitor of XPO1, which prevents substrates from binding to XPO1, thereby disrupting the nuclear export of proteins, and thus, may lead to inhibition of tumor growth (Journal of Clinical Oncology 33, no. 15_suppl).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable SL-801 Preclinical - Cell line xenograft Actionable In a preclinical study, SL-801 resulted in tumor growth inhibition in xenograft models with various advanced solid tumors (Journal of Clinical Oncology 33, no. 15_suppl). detail...