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|Therapy Name||Dexamethasone + Ixazomib + Lenalidomide + Tasquinimod|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Ixazomib||Ninlaro||MLN9708||Ninlaro (ixazomib) inhibits proteosome activity, resulting in accumulation of misfolded proteins, inhibition of pathway signaling, and potentially leading to cell death (PMID: 20160034). Ninlaro (ixazomib) in combination with Revlimid (lenalidomide) and dexamethasone is FDA approved for use in patients with multiple myeloma who have received at least one prior therapy (FDA.gov)|
|Lenalidomide||Revlimid||IMiD-1||Revlimid (lenalidomide) is a thalidomide analog which regulates cytokine production and stimulates T cells and NK cells activity (PMID: 24328678). Revlimid (lenalidomide) is FDA approved for use in multiple myeloma, relapsed or refractory Mantle cell lymphoma, and in combination with a rituximab product in follicular lymphoma and marginal zone lymphoma (FDA.gov).|
|Tasquinimod||ABR-215050|TASQ||Tasquinimod is a small molecule that exerts anti-tumor activity through both stimulation of immune response and inhibition of tumor angiogenesis (PMID: 24162378, PMID: 30431595).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04405167||Phase I||Tasquinimod Dexamethasone + Ixazomib + Lenalidomide + Tasquinimod||Tasquinimod for the Treatment of Relapsed or Refractory Myeloma||Recruiting||USA||0|