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Therapy Name BO-112
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BO-112 BO 112|BO112 BO-112 is a nanoparticle formulation of a synthetic double stranded RNA (poly I:C) complex, which potentially enhances anti-tumor immune response, induces apoptosis, and decreases tumor growth (PMID: 31046839).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown melanoma not applicable BO-112 Preclinical - Patient cell culture Actionable In a preclinical study, BO-112 treatment inhibited cell viability and induced apoptosis in mouse melanoma cells, and induced cytotoxicity and increased apoptosis in cells derived from metastatic lesions of melanoma patients in culture, and intratumoral delivery of BO-112 enhanced infiltration of T-lymphocytes, reduced tumor growth, and delayed progression in syngeneic mouse models (PMID: 31046839). 31046839
Unknown unknown colon cancer not applicable BO-112 Preclinical - Cell culture Actionable In a preclinical study, BO-112 treatment inhibited viability of mouse colon carcinoma cells, and reduced cell viability, and induced cytotoxicity and apoptosis in human colon cancer cell lines in culture, and intratumoral delivery of BO-112 reduced tumor growth in a syngeneic mouse model of colon carcinoma (PMID: 31046839). 31046839
Unknown unknown breast cancer not applicable BO-112 Preclinical - Cell culture Actionable In a preclinical study, BO-112 treatment induced cytotoxicity in human breast cancer cell lines and inhibited viability of mouse triple-negative breast cancer (TNBC) cells in culture, and intratumoral delivery of BO-112 reduced tumor growth in a syngeneic mouse model of TNBC (PMID: 31046839). 31046839

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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